0102030405
Pure Myristoyl Hexapeptide-16 Advanced Dermal Filler Complex
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Product Description
1. Mechanism of Action (MOA)
Myristoyl Hexapeptide-16 is a synthetic, lipopeptide engineered to target the appearance of deep wrinkles and loss of skin volume by mimicking the action of SNAP-25, a key protein involved in neuronal exocytosis.
*Inhibition of SNARE Complex Formation: The peptide's sequence is designed to competitively inhibit the formation of the SNARE complex, which is essential for the fusion of synaptic vesicles with the presynaptic membrane.
Physiological Result: By partially inhibiting this complex, Myristoyl Hexapeptide-16 reduces the release of catecholamines (e.g., norepinephrine) from the nerve endings that control specific facial muscles responsible for dynamic expression lines. This leads to a visible reduction in the intensity and depth of expression wrinkles, particularly on the forehead and around the eyes.
*Stimulation of Extracellular Matrix (ECM) Components: Beyond its neuromodulatory action, the peptide has been shown to promote the synthesis of key dermal components.
Physiological Result: It enhances the production of Collagen I, Collagen IV, and Hyaluronic Acid, contributing to improved skin density, hydration, and overall volume, leading to a plumper appearance.
2. In Vitro Efficacy Data
SNARE Complex Inhibition: In vitro studies using neuronal cell models demonstrate that Myristoyl Hexapeptide-16 effectively reduces the release of neurotransmitters by interfering with the SNARE complex assembly.
ECM Stimulation: Data from human dermal fibroblast cultures show a significant upregulation in the production of Collagen I (by >120%) and Hyaluronic Acid (by >90%) after treatment with Myristoyl Hexapeptide-16, compared to untreated controls.
Cell Viability: The peptide shows no cytotoxic effects on human skin cells at recommended concentrations, confirming its safety for cosmetic use.
3. Clinical Results
Human clinical trials over 28 to 56 days have demonstrated significant cosmetic benefits:
Reduction in Wrinkle Depth & Volume: Instrumental analysis (e.g., PRIMOS, skin replicas) showed a significant reduction (up to 25%) in the depth and volume of deep wrinkles, especially forehead lines and crow's feet, after 56 days of use.
Improvement in Skin Hydration & Elasticity: Corneometer and Cutometer measurements confirmed a marked improvement in skin hydration (over 30%) and elasticity (over 15%).
Visual Improvement: A high percentage of subjects (over 80%) self-assessed their skin as looking "smoother," "more supple," and "youthfully plumped."
Safety Profile
Myristoyl Hexapeptide-16 is a synthetic peptide with high biocompatibility. It is non-irritating and non-sensitizing at recommended use levels.
Compatibility
*Other peptides (e.g., Argireline, Matrixyl) *Hyaluronic Acid *Vitamins (e.g., Niacinamide, Vitamin C, E) *Plant extracts and antioxidants
PH & Temperature Stability
Stable in formulations with a pH range of 4.0-7.5.
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Recommended Usage & Formulations
Recommended Concentration: 3% - 6% (of the raw peptide material).
Ideal Formulations: Due to its myristoyl chain and water-soluble nature, it is well-suited for:
Targeted Wrinkle Serums
Intensive Age-Control Creams & Lotions
Eye Contour Gels & Creams
Plumping & Volumizing Ampoules
Application: Ideal for leave-on skincare products aimed at reducing deep expression lines and improving skin volume.
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Dual-Action Mechanism
Uniquely combines neuromodulatory action (relaxing expression lines) with ECM stimulation (plumping the skin) for comprehensive anti-aging.
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Targets Deep Wrinkles
Clinically proven to reduce the depth and volume of stubborn expression lines, such as forehead wrinkles and crow's feet.
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Restores Skin Volume
Enhances the skin's natural levels of collagen and hyaluronic acid, leading to a visibly plumper, more hydrated complexion.
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Safe & Versatile
Excellent tolerance and compatibility, making it suitable for integration into various anti-aging and wrinkle-focused formulations.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available